[76] Four-membered rings with one sulfur and one nitrogen atom. François Richard, Jennifer Ciesielski, Stellios Arseniyadis in Comprehensive Heterocyclic Chemistry IV, (Ed. G. Evano), Elsevier (submitted).

[75] O-Allylated Pudovik and Passerini Adducts as Versatile Templates for Product Diversification. Mansour Dolé Kerim, Tania Katsina, Martin Cattoen, Nicolas Fincias, Stellios Arseniyadis,* Laurent El Kaïm* (submitted)

[74] Direct access to highly enantioenriched α-branched acrylonitriles through a one-pot sequential asymmetric Michael addition/retro-Dieckmann/retro-Michael fragmentation cascade. Nicolas Duchemin, Martin Cattoen, Oscar Gayraud, Silvia Anselmi, Bilal Siddiq, Roberto Buccafusca, Marc Daumas, Vincent Ferey, Michael Smietana, Stellios Arseniyadis* Org. Lett. 2020 (in press)

[73] Aerobic Oxidation of Alcohols Using Catalytic DDQ/HNO3. Tania Katsina, Louis Clavier, Jean-François Giffard, Nayane Macedo Portela da Silva, Jean Fournier, Chloé Copin, Stellios Arseniyadis,* Alexandre Jean* Org. Process Res. Dev. 2020 (in press).

[72] DNA-based asymmetric inverse electron-demand hetero-Diels-Alder. Justine Mansot, Jimmy Lauberteaux, Aurélien Lebrun, Marc Mauduit, Jean-Jacques Vasseur, Renata Marcia de Figueiredo, Stellios Arseniyadis,* Jean-Marc Campagne* and Michael Smietana* Chem. Eur. J. 2020, 26, 3519-3523.

[71] A Sequential palladium‑catalyzed allylic alkylation/retro-Dieckmann fragmentation strategy for the synthesis of α-substituted acrylonitriles. Tania Katsina, Sachi Sharma, Roberto Buccafusca, Derek J. Quinn, Thomas S. Moody, Stellios Arseniyadis* Org. Lett201921, 9348-9352.

[70] Spatial and temporal control of chemical processes. Sidonie Aubert, Marine Bezagu, Alan C. Spivey,* Stellios Arseniyadis* Nature Rev. Chem. 20193, 706–722.

[69] A Unified Strategy for the Synthesis of Difluoromethyl- and Vinylfluoride-containing Scaffolds. Nicolas Duchemin, Roberto Buccafusca, Marc Daumas, Vincent Ferey, Stellios Arseniyadis*. Org. Lett. 2019, 21, 8205-8210.

  • ChemRxiv 2019 (DOI: 10.26434/chemrxiv.8091314.v1).
  • Highlighted in OPR&D.

[68] A rational quest for selectivity through precise ligand-positioning in the tandem DNA-catalysed Friedel-Crafts alkylation/asymmetric protonation. Justine Mansot, Sidonie Aubert, Nicolas Duchemin, Jean-Jacques Vasseur, Stellios Arseniyadis,* Michael Smietana* Chem. Sci. 2019, 10, 2875-2881.

[67] A sequential Pd-AAA/CM/Cope rearrangement strategy for the stereoselective synthesis of γ-butenolides. Sidonie Aubert, Tania Katsina, Stellios Arseniyadis* Org. Lett. 2019, 21 , 2231-2235.


[66] Asymmetric synthesis of α-quaternary γ-lactams through palladium-catalyzed asymmetric allylic alkylation. Tao Song, Stellios Arseniyadis,* Janine Cossy* Org. Lett. 2019, 21, 603-607.

[65] α,β-Unsaturated 2-acyl-imidazoles in asymmetric biohybrid catalysis. Justine Mansot, Jean-Jacques Vasseur, Stellios Arseniyadis,* and Michael Smietana* ChemCatChem. 2019, 11, 5686–5704.

[64] DNA-templated [2+2] photocycloaddition: A straightforward entry into the aplysinopsin family of natural products. Nicolas Duchemin, Adam Skiredj, Justine Mansot, Karine Leblanc, Jean-Jacques Vasseur, Mehdi A. Beniddir, Laurent Evanno,* Erwan Poupon,* Michael Smietana,* Stellios Arseniyadis* Angew. Chem. Int. Ed. 2018, 57, 11786-11791. Highlighted in Nature Reviews Chemistry and in the CNRS website.

[63] Challenges and opportunities in DNA-based asymmetric catalysis. Michael Smietana,* Stellios Arseniyadis* Chimia 2018, 72630-634 - invited article.

[62] Highly enantioselective, base-free synthesis of α-quaternary succinimides through catalytic asymmetric allylic alkylation. Tao Song, Stellios Arseniyadis,* Janine Cossy* Chem. Eur. J. 2018, 24, 8076-8080 (selected as a Hot Paper). Highlighted in Synfact.

[61] Palladium-catalyzed asymmetric allylic alkylation of 4-substituted isoxazolidin-5-ones: A straightforward access to β2,2‑amino acids. Marllon Nascimento de Oliveira, Stellios Arseniyadis,* Janine Cossy* Chem. Eur. J. 201824, 4810-4814.

[60] Palladium-catalysed O-allylation of α-hydroxyphosphonates: An expedient entry into phosphono-oxaheterocycles. Mansour Dolé Kerim, Martin Cattoen, Nicolas Fincias, Aurélie Dos Santos, Stellios Arseniyadis,* Laurent El Kaïm* Adv. Synth. & Catal. 2018360, 449-454 (selected as a Very Important Publication).

[59] Recent applications of Kagan's reagent (SmI2) in natural product synthesis. Erica Benedetti, Cyril Bressy, Michael Smietana, Stellios Arseniyadis in Efficiency in Natural Products Total Synthesis, (Eds. P.-Q. Huang, Z.-J. Yao, R. P. Hsung), Wiley 2018, ch 8, 319-344.

[58] Multicomponent reactions in natural product synthesis. Michael Smietana, Erica Benedetti, Cyril Bressy, Stellios Arseniyadis in Efficiency in Natural Products Total Synthesis, (Eds. P.-Q. Huang, Z.-J. Yao, R. P. Hsung), Wiley 2018, ch 6, 273-295.

[57] Dinucleating Schiff base ligand in Zn/4f coordination chemistry: Synthetic challenges and catalytic activity evaluation. Stavroula I. Sampani, Sidonie Aubert, Martin Cattoen, Kieran Griffiths, Alaa Abdul-Sada, Geoffrey R. Akien, Graham J. Tizzard, Simon J. Coles, Stellios Arseniyadis,* George E. Kostakis* Dalton Trans. 2018, 47, 4486-4493.

[56] A decade of DNA-hybrid catalysis: from innovation to comprehension. Nicolas Duchemin, Isabelle Heath-Apostolopoulos, Michael Smietana,* Stellios Arseniyadis* Org. Biomol. Chem. 2017, 15, 7072-7087.

[55] In situ targeted activation of a glucuronide prodrug using ultrasound-triggered release of composite droplets. Marine Bezagu, Jonathan Clarhaut, Brigitte Renoux, Fabrice Monti, Mickael Tanter, Patrick Tabeling,* Janine Cossy,* Olivier Couture, Sébastien Papot,* Stellios Arseniyadis* Eur. J. Med. Chem. 2017142, 2-7.

Image 1

[54] A Pd-AAA approach to a-quaternary g-butyrolactones. Marllon Nascimento de Oliveira, Jeremy Fournier, Stellios Arseniyadis,* Janine Cossy* Org. Lett. 201719, 14-17.

[53] Catalyse asymétrique innovante à base d’ADN. Stellios Arseniyadis,* Nicolas Duchemin, Isabelle Heath-Apostolopoulos, Michael Smietana* l'Actualité Chimique 2017, 417, 17-27.

[52] Des produits naturels au développement d’outils synthétiques. Stellios Arseniyadis l'Actualité Chimique 2016, 413, 7-18.

[51] Total synthesis of putative 11-epi-lyngbouilloside aglycon. Amandine Kolleth, Julian Gebauer, Abdelatif ElMarrouni, Raphael Lebeuf, Céline Prévost, Eric Brohan, Stellios Arseniyadis,* Janine Cossy* Front. Chem. 20164, Article 34.

[50] Synthesis of polyketides. Cyril Bressy, Michael Smietana, Erica Benedetti, Stellios Arseniyadis in From Biosynthesis to Total Synthesis, (Ed. A. L. Zografos), Wiley 2016, ch 2, 19-129.

[49] Expanding biohybrid-mediated asymmetric catalysis into the realm of RNA. Nicolas Duchemin, Erica Benedetti, Lucas Bethge, Stefan Vonhoff, Sven Klussmann, Jean-Jacques Vasseur, Janine Cossy, Michael Smietana,* Stellios Arseniyadis* Chem. Commun201652, 8604-8607.

[48] Design, synthesis and binding affinity evaluation of Hoechst 33258 derivatives for the development of sequence-specific DNA-based asymmetric catalystsKaren Amirbekyan, Nicolas Duchemin, Erica Benedetti, Rinah Joseph, Aude Colon, Shiraz A. Markarian, Lucas Bethge, Stefan Vonhoff, Sven Klussmann, Janine Cossy, Jean-Jacques Vasseur, Stellios Arseniyadis,* Michael Smietana* ACS Catal. 20166, 3096-3105.

[47] Selective Tsuji-Trost type C-allylation of hydrazones: A straightforward entry into 4,5-dihydro pyrazoles. Hachemia Elhachemia, Martin Cattoen, Marie Cordier, Janine Cossy, Stellios Arseniyadis, Hocine Ilitki*, Laurent El Kaïm* Chem. Commun201652, 14490-14493.

[46] A fast and switchable microfluidic mixer based on ultrasound-induced vaporization of perfluorocarbon. Marine Bezagu, Stellios Arseniyadis,* Janine Cossy,* Olivier Couture, Mickael Tanter, Fabrice Monti, Patrick Tabeling* Lab Chip 2015, 15, 2025-2029.

[45] DNA-cellulose: An economical, fully recyclable and highly effective chiral biomaterial for asymmetric catalysis. Erica Benedetti, Nicolas Duchemin, Lucas Bethge, Stefan Vonhoff, Sven Klussmann, Jean-Jacques Vasseur, Janine Cossy, Michael Smietana,* Stellios Arseniyadis* Chem. Commun. 2015, 51, 6076-6079. Highlighted in Chemistry World and in the CNRS website.

Supported DNA

[44] Recent developments in alkyne borylations. Renaud Barberon, Erica Benedetti, Jean-Jacques Vasseur, Janine Cossy, Stellios Arseniyadis,* Michael Smietana,* Tetrahedron 201470, 8431-8452.

[43] High spatiotemporal control of spontaneous reactions using ultrasound-triggered composite droplets. Marine Bezagu, Claudia Errico, Victor Chaulot-Talmon, Fabrice Monti, Mickael Tanter, Patrick Tabeling,* Janine Cossy,* Stellios Arseniyadis,* Olivier Couture, J. Am. Chem. Soc. 2014, 136, 7205-7208. Highlighted in the CNRS website.

[42] Palladium-catalyzed allylic alkylation of allyl dienol carbonates: Reactivity, regioselectivity, enantioselectivity and synthetic applications. Stellios Arseniyadis,* Jérémy Fournier, Thangavelu Saravanan, Oscar Lozano, Sébastien Prevost, Alexis Archambeau, Candice Menozzi, Janine Cossy* Synlett 2013, 2350-2364. Special issue for the 5th Edition of the Young Investigator Workshop held in Marseille (invited article).

Synlett review

[41] DNA vs. mirror image DNA: A universal approach to tune the absolute configuration in DNA-based asymmetric catalysis. Jocelyn Wang, Erica Benedetti, Lucas Bethge, Stefan Vonhoff, Sven Klussmann, Jean-Jacques Vasseur, Janine Cossy, Michael Smietana,* Stellios Arseniyadis* Angew. Chem. Int. Ed. 201352, 11546-11549. Highlighted in the CNRS website.


[40] Non-enzymatic acylative kinetic resolution of primary allylic amines. Amandine Kolleth, Martin Cattoen, Stellios Arseniyadis,* Janine Cossy* Chem. Commun. 2013, 49, 9338-9340.

[39] Lyngbouilloside and related macrolides from marine cyanobacteria. Abdelatif ElMarrouni, Amandine Kolleth, Raphael Lebeuf, Julian Gebauer, Sébastien Prevost, Montserrat Heras, Stellios Arseniyadis,* Janine Cossy* Natural Product Communications 2013, 8, 965-972.

[38] Regio‐ and position selective reactions and desymmetrizationsAlan C. Spivey,* Stellios Arseniyadis* in Comprehensive Enantioselective Organocatalysis, Ed. P. Dalko, Wiley-VCH 2013, Vol 3, Chapter 41, 1225-1284.

[37] Palladium-catalyzed asymmetric allylic alkylation of cyclic dienol carbonates: Efficient route to enantioenriched g-butenolides bearing an all-carbon a-quaternary stereogenic center. Jeremy Fournier, Oscar Lozano, Candice Menozzi, Stellios Arseniyadis,* Janine Cossy* Angew. Chem. Int. Ed. 2013 52, 1257-1261 (Highlighted in Synfacts 2013, 4, 409).

[36] Kinetic resolution of propargylamines via a highly enantioselective non-enzymatic N-acylation process. Amandine Kolleth, Sarah Christoph, Stellios Arseniyadis,* Janine Cossy* Chem. Commun. 2012, 48, 10511-10513.

[35] Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)‑cystothiazole F. Aude Colon, Thomas J. Hoffman, Julian Gebauer, Jyotirmayee Dash, James H. Rigby, Stellios Arseniyadis,* Janine Cossy* Chem. Commun. 2012,48, 10508-10510.

[34] A modular and scalable one-pot synthesis of polysubstituted furans. Jeremy Fournier, Stellios Arseniyadis,* Janine Cossy* Angew. Chem. Int. Ed. 2012, 51, 7562-7566.

[33] DNA as a tool for molecular discovery. Michael Smietana,* Jean-Jacques Vasseur, Janine Cossy, Stellios Arseniyadis* in Modern Tools for the Synthesis of Complex Bioactive Molecules, (Eds.: J. Cossy, S. Arseniyadis), John Wiley & Sons, Inc., Hoboken, NJ, USA. 2012, 539-556.

[32] Total synthesis of nominal lyngbouilloside aglycon. Abdelatif ElMarrouni, Raphael Lebeuf, Julian Gebauer, Montserrat Heras, Stellios Arseniyadis,* Janine Cossy* Org. Lett. 2012, 14, 314-317.

[31] 2,6-bis[(4S)-4,5-Dihydro-4-(1-methylethyl)-5,5-diphenyl-2-oxazolyl] pyridine in electronic Encyclopedia of Organic Reagents (e-EROS), Wiley-VCH, 2011. Stellios Arseniyadis, Cyril Bressy.

[30] N-[(1S)-1-(Hydroxydiphenylmethyl)-3-methylbutyl]-2-pyrrolidinecarbox amide in electronic Encyclopedia of Organic Reagents (e-EROS), Wiley-VCH, 2011. Stellios Arseniyadis, Cyril Bressy.

[29] Studies towards the N-acylative kinetic resolution of NOBIN. Stellios Arseniyadis, Mohan Mahesh, Paul McDaid, Thomas Hampel, Stephen G. Davey, Alan C. Spivey* Coll. Czech. Chem. Commun. 2011, 76, 1239-1253.

[28] A concise approach towards the synthesis of WS75624 A and WS75624 B via the cross-metathesis of vinyl-functionalized thiazoles. Jyotirmayee Dash, Bruno Melillo, Stellios Arseniyadis,* Janine Cossy* Tetrahedron Lett. 2011, 52, 2246-2249 (Special issue in honour of Professor Harry H. Wasserman on the occasion of his 90th birthday).

[27] Expedient synthesis of a stereoisomer of acremolide B. Abdelatif ElMarrouni, Aya Fukuda, Montserrat Heras, Stellios Arseniyadis,* Janine Cossy* J. Org. Chem. 2010, 75, 8478-8486.

[26] Two concise total syntheses of (-)-bitungolide F. Abdelatif ElMarrouni, Shyamsunder R. Joolakanti, Aude Colon, Montserrat Heras, Stellios Arseniyadis,* Janine Cossy* Org. Lett. 2010, 12, 4074-4077.

[25] Stereoselective synthesis of the C1‑C11 and C12‑C34 fragments of mycalolide A. Thomas J. Hoffman, Amandine Kolleth, James H. Rigby, Stellios Arseniyadis,* Janine Cossy* Org. Lett. 2010, 12, 3348-3351.

[24] Total synthesis and structural revision of vannusals A and B. Synthesis of the originally assigned structure of Vannusal B. K. C. Nicolaou,* Adrian Ortiz, Hongjun Zhang, Philippe Dagneau, Andreas Lanver, Michael P. Jennings, Stellios Arseniyadis, Raffaella Faraoni, Dimitrios E. Lizos J. Am. Chem. Soc. 2010, 132, 7138-7152.

[23] Amine, alcohol & phosphine catalysts for acyl transfer reactions. Alan Spivey,* Stellios Arseniyadis* Topics in Current Chemistry: Asymmetric Organocatalysis, Ed. B. List, Springer Verlag 2010, Vol 291, Chapter 25, pp 233-280.

[22] Straightforward synthesis of the near-infrared fluorescent voltage-sensitive dye RH1691 and analogues thereof. Raphaël Lebeuf, Isabelle Férézou, Jean Rossier,Stellios Arseniyadis,* Janine Cossy* Org. Lett. 2009, 11, 4822-4825.

[21] Enantioselective organocatalytic conjugate reduction of b-azole a,b-unsaturated aldehydes. Thomas J. Hoffman, Jyotirmayee Dash, James H. Rigby, Stellios Arseniyadis,* Janine Cossy* Org. Lett. 2009, 11, 2756-2759.

[20] One-pot hydrosilylation/RCM/protodesilylation: Application to the synthesis of w-alkenyl a,b-unsaturated lactones. Cyril Bressy, Frédéric Barggigia, Mathieu Guyonnet, Stellios Arseniyadis, Janine Cossy* Synlett, 2009, 565-568.

[19] Asymmetric pentenylation of aldehydes: A new benchmark for the preparation of ethyl-substituted homoallylic alcohols. Ravindra P. Sonawane, Shyamsunder R. Joolakanti, Stellios Arseniyadis,* Janine Cossy* Synlett 2009, 213-216.

[18] Asymmetric total synthesis of the immunosuppressant (-)-pironetin. Cyril Bressy, Jean-Pierre Vors, Stefan Hillebrand, Stellios Arseniyadis, Janine Cossy* Angew. Chem, Int. Ed. 2008, 47, 10137-10140.

[17] Formal synthesis of leustroducsin B. Joëlle Moïse, Ravindra P. Sonawane, Camilla Corsi, Sebastian V. Wendeborn, Stellios Arseniyadis,* Janine Cossy* Synlett 2008, 2617-2620.

[16] Total synthesis of cystothiazole A by microwave-assisted olefin cross-metathesis. Julian Gebauer, Stellios Arseniyadis,* Janine Cossy* Eur. J. Org. Chem. 2008, 2701-2704.

[15] Synthesis of vinyl-functionalized oxazoles by olefin cross-metathesis. Thomas J. Hoffman, James H. Rigby, Stellios Arseniyadis, Janine Cossy* J. Org. Chem. 2008, 73, 2400-2403.

[14] Facile synthesis of the C1–C13 fragment of lyngbouilloside. Julian Gebauer, Stellios Arseniyadis,* Janine Cossy* Synlett 2008, 712-714.

[13] Non-enzymatic kinetic resolution of amines in ionic liquids. Cyrille Sabot, Pithani V. Subhash, Alain Valleix, Stellios Arseniyadis,* Charles Mioskowski,* Synlett 2008, 268-272.

[12] A concise total synthesis of melithiazole C. Julian Gebauer, Stellios Arseniyadis, Janine Cossy* Org. Lett. 2007, 9, 3425-3427.

[11] The chemistry and biology of epothilones – The wheel keeps turning. Karl-Heinz Altmann,* Bernhard Pfeiffer, Stellios Arseniyadis, Benjamin A. Pratt, K. C. Nicolaou* ChemMedChem 2007, 396-423.

[10] Cross-Metathesis between a-methylene-g-butyrolactone and olefins: A dramatic additive effect. Joëlle Moïse, Stellios Arseniyadis,* Janine Cossy* Org. Lett. 2007, 9, 1695-1698.

[9] Synthesis of vinyl-functionalized thiazoles by cross-metathesis and tandem Stille coupling/cross-metathesis. Jyotirmayee Dash, Stellios Arseniyadis, Janine Cossy* Adv. Synth. Cat. 2007, 349, 152-156.

[8] Molecular design and chemical synthesis of a highly potent epothilone. K. C. Nicolaou,* Benjamin A. Pratt, Stellios Arseniyadis, Markus Wartmann, Aurora O’Brate, Paraskevi Giannakakou ChemMedChem 2006, 1, 41-44.

[7] Rapid, room-temperature acylative kinetic resolution of sec-alcohols using atropisomeric 4-aminopyridine/triphenylphosphine catalysis. Alan C. Spivey,* Stellios Arseniyadis, Tomasz Fekner, Adrian Maddaford, David P. Leese Tetrahedron 2006, 62, 295-301.

[6] Unprecedented, fully recyclable, solid-supported reagent for the kinetic resolution of racemic amines through enantioselective N-acetylation. Stellios Arseniyadis, Pithani V. Subhash, Alain Valleix, Alain Wagner,* Charles Mioskowski* Chem. Commun. 2005, 26, 3310-3312 (Highlighted in Synfacts 2005, 1, 170).

[5] Tuning the enantioselective N-acetylation of racemic amines: A spectacular salt effect. Stellios Arseniyadis, Pithani V. Subhash, Alain Valleix, Suju P. Mathew,Donna G. Blackmond, Alain Wagner,* Charles Mioskowski* J. Am. Chem. Soc. 2005, 127, 6138-6139.

[4] Nucleophilic catalysis by 4-(dialkylamino)pyridines revisited - The search for optimal reactivity and selectivity. Alan C. Spivey,* Stellios Arseniyadis Angew. Chem. Int. Ed. 2004, 43, 5436-5441.

[3] Kinetic resolution of amines: A chemoselective and highly enantioselective acetylating agent with a unique solvent-induced reversal of stereoselectivity. Stellios Arseniyadis, Alain Valleix, Alain Wagner,* Charles Mioskowski* Angew. Chem. Int. Ed. 2004, 43, 3314-3317.

[2] Resin bound 4-phenyl-1,2-dihydroquinoline (DHQ): An new safety-catch linker for solid phase organic synthesis (SPOS). Stellios Arseniyadis, Alain Wagner,* Charles Mioskowski* Tetrahedron Lett. 2004, 45, 2251-2253.

[1] A straightforward preparation of amino-polystyrene resin from Merrifield resin. Stellios Arseniyadis, Alain Wagner,* Charles Mioskowski* Tetrahedron Lett. 2002, 43, 9717-9719.


Chemical synthesis of a highly potent epothilone. Nicolaou, K. C.; Pratt, B.; Arseniyadis, S. (International publication number: WO 2007/062288 International publication date: 31/05/2007).


[2] Modern tools for the synthesis of complex bioactive molecules. Janine Cossy, Stellios Arseniyadis, John Wiley & Sons, Inc., Hoboken, NJ, USA (2012), ISBN-13: 978-0470616185.

[1] Metathesis in natural product synthesis. Janine Cossy, Stellios Arseniyadis, Christophe Meyer, Wiley-VCH, Weinheim, Germany (2010), ISBN-13: 978-3-527-32440-8.